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Overview
Novel potent STAT5 SH2 domain inhibitor, efficiently blocking pathological levels of STAT5 activity in AML
Chemical Properties
| Molecular Formula | C37H36ClF5N2O5 |
| Molecular Weight | 751.21 |
| CAS Numbers | 1834571-82-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 4-(2-((N-(4-chlorobenzyl)-2,3,4,5,6-pentafluorophenyl)sulfonamido)-N-(3,5-di-tert-butylbenzyl)acetamido)benzoic acid |
| InChl Key | NMQUSJQZQWKQBL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C37H36ClF5N2O5S/c1-36(2,3)24-15-22(16-25(17-24)37(4,5)6)19-45(27-13-9-23(10-14-27)35(47)48)28(46)20-44(18-21-7-11-26(38)12-8-21)51(49,50)34-32(42)30(40)29(39)31(41)33(34)43/h7-17H,18-20H2,1-6H3,(H,47,48) |
| SMILES Code | FC1=C(F)C(F)=C(S(=O)(N(CC(N(CC2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)C3=CC=C(C(O)=O)C=C3)=O)CC4=CC=C(Cl)C=C4)=O)C(F)=C1F |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
AC4130; AC-4130; AC4-130; AC-4-130
References
Wingelhofer B, Maurer B, Heyes EC, Cumaraswamy AA, Berger-Becvar A, de Araujo ED, Orlova A, Freund P, Ruge F, Park J, Tin G, Ahmar S, Lardeau CH, Sadovnik I, Bajusz D, Keserű GM, Grebien F, Kubicek S, Valent P, Gunning PT, Moriggl R. Pharmacologic inhibition of STAT5 in acute myeloid leukemia. Leukemia. 2018 May;32(5):1135-1146