2'-Fucosyllactose [41263-94-9]

Biological Activity

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines.

2'-Fucosyllactose (2'-FL; 100 mg (200 μL); i.g.; daily, for 4 d; C57BL/6 mice with AIEC infection) inhibits AIEC infection and inflammation in vivo.

Chemical Information

Molecular Weight	488.44
Formula	C18H32O15
CAS Number	41263-94-9
Solubility (25°C)	Water
Storage	-20°C, dry, sealed

References

[1] Jin Wang, et al. Foods. 2'-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway

[2] Yingying Zhu, et al. Crit Rev Food Sci Nutr. Recent advances on 2'-fucosyllactose: physiological properties, applications, and production approaches

[3] Wenting Zhou, et al. ACS Synth Biol. Biotechnological Production of 2'-Fucosyllactose: A Prevalent Fucosylated Human Milk Oligosaccharide

[4] Chhinder P Sodhi, et al. Pediatr Res. The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

[5] Yvan Vandenplas, et al. Nutrients. Human Milk Oligosaccharides: 2'-Fucosyllactose (2'-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula