Tamanho : 1mg(22.91mMx100uLinEthanol)
Telefone : +1 850 650 7790
Synonyms: Oleoyl-sn-3-Glycerophosphate, 1-Oleoyl LPA
| Description | 1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can exert multiple biological effects in various disease states of the kidney by activating a complex network of at least six homologous G protein-coupled receptors and their heterotrimeric G proteins. 1-Oleoyl Lysophosphatidic Acid promotes polarization of BV-2 and primary murine microglia toward an M1-like phenotype and can be used to study cancer and atherosclerosis. |
| In vivo | METHODS: 1-Oleoyl Lysophosphatidic Acid(0.4-2 μg, i.v. for 9 weeks) treated rats and behaviorally assessed. RESULTS: 1-Oleoyl Lysophosphatidic Acid induced anxiety-like responses in the elevated plus maze (EPM). [5] |
| Synonyms | Oleoyl-sn-3-Glycerophosphate, 1-Oleoyl LPA |
| Molecular Weight | 436.52 |
| Formula | C21H41O7P |
| Cas No. | 65528-98-5 |
| Smiles | O(C(CCCCCCC/C=C\CCCCCCCC)=O)C[C@H](COP(=O)(O)O)O |
| Relative Density. | 1.103 g/cm3 (Predicted) |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol: 10 mg/mL (22.91 mM), Sonication is recommended. PBS (pH 7.2): 1 mg/mL (2.29 mM), Sonication is recommended. DMF: 1 mg/mL (2.29 mM), Sonication is recommended. DMSO: 1 mg/mL (2.29 mM), Sonication is recommended. PBS (pH 7.2): 1 mg/mL (2.29 mM), Sonication is recommended. |
Solution Preparation Table | |
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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