(+/-)-Blebbistatin
Product Code
TRC-B592490
CAS Number
674289-55-5
Product Format
Neat
Molecular Formula
C18 H16 N2 O2
Molecular Weight
292.33
Purity
>95% (HPLC)
Documentation
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Product Information
Chemical Data
Analyte Name
(+/-)-Blebbistatin
CAS Number
674289-55-5
Molecular Formula
C18 H16 N2 O2
Molecular Weight
292.33
Accurate Mass
292.1212
SMILES
Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c4ccccc4
InChI
InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
IUPAC
3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
Purity
>95% (HPLC)
Product Description
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100uM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II
References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)